Administration of intravenous infliximab for prevention of peritoneal adhesions formation in rats

Objectives: To investigate the effects of intravenous infliximab in preventing the formation of peritoneal adhesions in an animal model of rat

Methods: This was an experimental study being performed in animal laboratory of Shiraz University of Medical Sciences during 2012. Sixty albino rats were randomly assigned in to three groups by Random Design Method. The first group received single infliximab injection [n=20], the second one received double infliximab injection [n=20] and the third received nothing [n=20], after receiving intra-peritoneal injection of talc for induction of peritoneal adhesions. All the animals were sacrificed after 6 weeks and the peritoneal adhesions were evaluated according to Nair classification

Results: We observed that the mean adhesion grade was lower in those who received double dose of infliximib when compared to single dose and controls. However the difference did not reach a significant value [p=0.178]. The grade of peritoneal adhesion was also comparable between the three study groups [p=0.103]. The mean number of 1st WBC count was also comparable between three study groups [p=0.382]. We observed that 2 nd WBC count was also comparable between two study groups [p=0.317]

Conclusion: Administration of intravenous infliximab after intraabdominal surgicalprocedures would not prevent the formation of peritoneal adhesions in animal model of albino rat

Ruptured Meckel's mesodiverticulum and Meckel's diverticulum following blunt abdominal trauma

To present a case of simultaneous rupture of Meckel's diverticulum and mesodiverticulum with abdominal pain following a blunt trauma to the abdomen, sustained during an automobile accident. Following a head-on automobile collision a 36-year-old man was referred to the emergency room with abdominal pain, guarding and rigidity and was taken to the operating theater with a preoperative impression of peritonitis due to rupture of a hollow viscus. Upon abdominal exploration, ruptured Meckel's diverticulum [from the base] and ileum with active bleeding from mesodiverticulum was found. The ileum was repaired in two layers: a segmental bowel resection including Meckel's diverticulum and the gastrointestinal tube anastomosed without any tension. The patient has a normal postoperative course. This case shows that a blunt abdominal trauma can tear the mesodiverticulum and rupture the Meckel's diverticular base simultaneously, resulting in hemoperitoneum and chemical peritonitis. Diagnosis and management of this type of injury are basically the same as those of acute surgical abdomen following trauma